Senior Scientist, Computational Chemistry/AI/ML
Location: Boston, USA Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, highly skilled, and creative computational chemist/AI/ML expert to join MRT’s computational chemistry team. You will connect chemistry to biology to rationally design a new class of novel molecular glue degraders (MGDs). The successful candidate will be involved in many aspects of chemistry research activities, interface with team members on the development of unique chemical matter to solve novel biological problems and contribute to the development of our growing program portfolio. You will work tightly with chemistry, biology, and the rest of the data science team to develop, validate and optimize novel chemical matter to treat patients. In this position, you will make significant contributions at the forefront of drug discovery. Monte Rosa is based in Boston and Basel. Responsibilities Develop Innovative Computational Methods : Design and implement new computational and machine learning approaches to support rational Molecular Glue Degrader (MGD) design. Project Team Leadership : Serve as a critical contributor on project teams, guiding MGD design and optimization by integrating computational techniques such as molecular docking, ligand-based design, diversity and conformational analyses, among others. Automation of Discovery Chemistry : Lead efforts to automate early-stage discovery chemistry through a combination of data science, cheminformatics, and AI/ML. Compound Collection Strategy : Continuously refine and execute Monte Rosa’s computational strategy for expanding the compound collection to enhance discovery capabilities. Large-Scale Data Analysis : Analyze internal high-throughput screening (HTS) data to generate large-scale (SAR) insights, driving hit expansion and supporting the growth of Monte Rosa’s library. Strategic Presentation and Guidance : Present findings and strategic insights to project teams, ensuring timely analysis to advance key project objectives. Desired Skills And Experience...we believe in our team members having meaningful experiences that help them build and develop skills for a career. The role of a Starbucks Barista can provide you with the: Knowledge of guest service fundamentals and experience building a guest first culture in Starbucks...
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